Hello everyone! Today I have a comparison review of the Mizon Hyaluronic Acid 100 Ampoule and the Hylamide Low Molecular HA for all o’ y’all to see! Without further ado, and there’s been months of ado, let’s get on with it!
I’ll start off with a bit about the absolute amazingness that is Hyaluronic Acid and some hyaluronic acid facts:
- It has a couple names – sodium hyaluronate, hyaluronic acid and hyaluronan. To make make life easier for all of us, let’s call it HA (Hyaluronic Acid).
- HA is a glycosaminoglycan.
- HA is the chief component of the extra cellular matrix (the tissue that provides structural support to cells).
- 50% of the body’s amount of HA is in the skin. The average human has around 15 grams of HA in the body, a third of which is turned over aka degraded and synthesized every day.
- HA is partly responsible for the resilience of cartilage and its ability to resist compression.
- Hyaluronic acid can hold up to 6 liters of water per gram!
- HA is a ‘smart nutrient’ as it adjust how much moisture it absorbs based on the humidity relative to the season and climate.
- Hyaluronic Acid is a major component of skin where it benefits tissue repair and protection. When applied in an HA cream or serum, hyaluronic acid forms an air permeable layer. The protective barrier on the skin locks in moisture.
- One of the most skin damaging elements are UVB rays from the sun. Hyaluronic acid benefits the skin as it protects the skin from UVB rays (and the scavenging reactive oxygen species they generate), which can cause sunspots.
- Difference between sodium hyaluronate and hyaluronic acid? Sodium hyaluronate is a salt derived from hyaluronic acid that does all that HA does. It is a cleaned up form of the native molecule which tends to bind things like lipids and proteins. Sodium hyaluronate will not penetrate the skin significantly because it is still a huge molecule. That, however, doesn’t mean it isn’t still beneficial to the skin. (from drjohn’s reply to G’s question in the comments section)
- CD44 is the receptor of HA and HA cannot be put to use if there is nothing to receive it and put it to use, basically. As we age, we lose both the HA and the CD44 in our skin.
- It has a very quick turnover rate. HA has a half-life of 3 to 5 min in the blood, less than a day in the skin and 1 to 3 weeks in the cartilage.
Okay now time for some ~contradictory~ material on HA. I did ask Stephen from KindofStephen about this post and he said that a lot of people take research based on injections and assume it’s the same for topical. He also said LMW-HA under 40 kDa is potentially ‘bad’. (Girl don’t even ask me I don’t know what kDa is)
So I guess, take the post (by Barefacedtruth.com) with a grain of salt? If you want some key points, here ya go:
- High Molecular Weight-Hyaluronic Acid (HMW-HA) has been shown to reduce the effects of the inflammatory response suggesting that it promotes regenerative healing in adult wounds.
- Low Molecular Weight-Hyaluronic Acid (LMW-HA) basically makes the inflammatory response stronger.
- You’re better off applying HMW-HA products at the last step of your skincare because it forms a natural barrier so it’s most efficient as a last step.
- LMW-HA is a marketing ploy to make ‘their HA better than competitors’ HA’.
and if you’re curious, here are the studies they used to back themselves up:
- Targeting Inflammatory Cytokines and Extracellular Matrix Composition to Promote Wound Regeneration.
- Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4.
- Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation.
Functions of Hyaluronic Acid (in the skin and body):
- An amazing humectant, as mentioned before. Can provide and maintain hydration to the skin. Works for all skin types too! However, in dry environments, HA can potentially draw moisture out from within your skin to give a plumper appearance but dries out your skin in the long run.
- Can plump fine lines on the skin and give the skin a younger looking appearance.
- Can protect skin from free radical damage and aid in wound healing.
- Increasing viscosity and reducing permeability of extracellular fluid.
- Contributing to mechanical resilience and suppleness of the skin.
- Regulation of tissues repair.
- Regulation of movement and proliferation of cells.
- Regulation of immune and inflammatory responses.
Now that you know more about HA or have skipped through the science-y BS, let’s move on to the actual products!
Edit: I forgot to mention my skin ‘profile’ – I’m 19 years old with skin that’s dry and dehydrated but can also get clogged easily.
Let’s start with the Mizon ampoule!
Mizon Original Skin Energy Hyaluronic Acid 100 Ampoule
Mizons Hyaluronic Acid Ampoule is part of Original Skin Energy Ampoules that is an essential factor solution for your skins problem areas. Through its wrinkle improvement, achieve stronger, robust skin energy. And by filling skin with abundant, deeply rich moisture, it takes responsibility of the inside of your skin as well. Its hydration improves skin elasticity, texture, and firms to create glossy, healthy skin without a sticky mess. For those with skin without a lot of moisture, the ampoule should be a fundament part of your skin care. – According to Amazon.
I bought it for $14 on Amazon
Where it fits in your routine
Either you can stick to the lightest to thickest consistency rule and apply it accordingly with the rest of your routine, or mix it in with your skincare steps. I mixed it into a toner/skin to boost its hydrating ability, mixed into a lightweight emulsion to do the same (works well on days when I didn’t have time to do my full routine) or what I haven’t done with this product but have done with others, is to mix it in with a cream. Mixing liquids with creams makes them more lightweight and helps them absorb faster but still have their moisturizing capability.
A light, baby blue-ish glass bottle packaging, the little shiny bit is plastic. Das it. Also the dropper doesn’t reach anywhere near the botton so I did have to pour the drops of the product out (you’d best believe I did bitch I ain’t wastin’ nothin)
A cloudy colored lightweight liquid that’s not sticky at all. A full dropper’s worth will sink in with ease.
My notes said ‘very subtle skincarey scent’. Take that for what you will.
PAO (period after opening aka the open jar symbol on the back of cosmetics) is 12 months so once you open the bottle up, you’ve got a year to finish it. I was pretty heavy handed with this stuff when I used it without mixing it into anything but it lasted me from October to December but how long it lasts purely depends on if you use drops or dash this on ya face like I dash sesame oil onto almost everything I eat.
Sodium Hyaluronate – ya know what dis is already
Ceramide 3 – one of the essential parts of the skin’s upper layers. Can aid skin barrier repair, helps fight aging associated xerosis, can help with eczema and protect skin from certain irritants. Can decrease TEWL (Trans Epidermal Water Loss).
Betula Platyphylla Japonica Juice – Birch Sap. Skin conditioning agent. Able to mimic the skin’s NMF (Natural Moisturizing Factor).
Portaluca Oleracea Extract – sciencey word for Purslane. Anti-irritant, antioxidant.
Scutellaria Baicalensis Root Extract – sciencey word for skullcap. Antioxidant and skin soothing properties.
Achillea Millefolium Extract – sciencey word for yarrow. Can potentially rejuvenate the skin surface. Can reduce flaking and restore suppleness to the skin.
Gentiana Lutea Root Extract – Antioxidant and can have skin soothing benefits.
Rubus Idaeus (Raspberry) Fruit Extract – Rubus Idaeus or red raspberry extract is great for hydrating and anti-aging. It’s also involved with ceramide production. (Yes I did copy this from my Mizon snail cream review.)
Irritants and acne triggers
4 weak potential acne triggers – Butylene Glycol (1), Stearic Acid (2), PEG-100 Stearate (1), Triethanolamine (2) and 1 weak potential skin irritant – Carbomer (1).
Full ingredient list
Water, Sodium Hyaluronate, Copper Tripeptide-1, Butylene Glycol, Sclerotium Gum, 1,2-octanediol, Ethylhexyl-glycerin, Tropolone, Hydrogenated Polydecene, Caprylic/capric Triglyceride, Hydrogenated Lecithin, Stearic Acid, C12-c20alkyl Glucoside, C13-22 Alcohol, Glyceryl Stearate, PEG-100 Stearate, Cholesteryl Hydroxystearate, Cholesterol, Ceramide 3, Triethanolamine, Carbomer, Betula Platypyhlla Japonica Juice, Portaluca Oleracea Extract, Scutellaria Baicalensis Root Extract, Astragalus Membranaceus Root Extract, Amica Montana Flower Extract, Artemisia Absinthium Extract, Achillea Millefolium Extract, Gentiana Lutea Root Extract, Rubus Idaeus (Rasberry) Fruit Extract, Beta-Glucan, Adenosine, Carbomer, Triethanolamine, Disodium EDTA
My experience and thoughts
This was just okay. When I used it on its own it barely did anything for me, so later I just tried a whole pipette-ful and that gave me some noticeable change in bounciness and did hydrate okay. What was cool was it sort of just disappeared into the skin. Eventually, I ended up using this to ‘boost’ the hydrating ability of other products so I usually mixed it into toners or emulsions and I honestly liked it best like that. It sort of thinned out the consistency of cream/emulsion type products and just added some (more) humectant quality to products.
Meh, won’t repurchase. Cute color and packaging but it didn’t make a difference that I could notice on my skin. I felt like my serums can hydrate well enough on their own without this ampoule. Wouldn’t recommend either because of its meh-ness.
Hylamide Low Molecular HA
Claims – according to the Hylamide website (not exactly claims but it’s what I could find for claims lol)
VERY LOW-MOLECULAR HA
Offers rehydration with better topical absorption than ordinary HA
Hyaluronic Acid Ferment
Purified non-animal source hyaluronic acid for oil-free surface hydration
Low-molecular form of HA to support lower to middle skin rehydration
Novel technology acts as a precursor to HA and encourages a plump look
Tamarind-derived HA technology improves the look of skin elasticity
Where it fits in your routine
Same thing with the thinnest to thickest consistency rule. I didn’t use this as an additive to other products and the directions on the website don’t ask you to either but boi it’s your life and you do what you wanna.
Nice frosted glass bottle with a sticker around it. The material of the dropper portion is plastic, rubber for the squeezy part and glass for the pipette.
The texture was thick/viscous but insanely lightweight. The viscosity is most probably coming from the hydrolyzed yeast, algae and tamarind seed gum and I like it because it helps a little amount spread and go a long way.
Nothing I could detect.
12 months after opening.
Sodium Hyaluronate – I ain’t gon repeat myself boi scroll on up if ya done skipped it
Hydrolyzed Yeast Extract – A natural source of beta glucan and therefore an antioxidant.
Tamarindus Indica Seed Gum – Tamarind seed gum. Acts as a humectant or moisturizer. Is a polysaccharide that moisturizes and smoothes the skin. According to manufacturer info, it also improves the skin’s elasticity and leaves an extremely pleasant velvety feeling on the skin.
Irritants and acne triggers
Hexylene Glycol – rated 2 as a potential acne trigger and 1 as a potential irritant by Cosdna.
Full ingredient list
Aqua (Water), Hydrolyzed Yeast Extract, Pentylene Glycol, Tamarindus Indica Seed Gum, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate, Tremella Fuciformis Sporocarp Extract, Ahnfeltia Concinna Extract, Lecithin, Glycerin, Betaine, Polyacrylate Crosspolymer-6, Cetyl Hydroxyethylcellulose, Polyglucuronic Acid, Trisodium Ethylenediamine Disuccinate, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Potassium Sorbate, Sodium Benzoate, Caprylyl Glycol, Hexylene Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.
My experience and thoughts
I’ll say it here, love this SO much more than the Mizon! For so many reasons, this not only has low molecular HA which absorbs better into the skin but it also helps it to be received better by the skin (I’m guessing it helps by aiding in CD44 production?). A drop usually did it for my whole face (and girl I got a big face) and it really left my skin feeling bouncier and more hydrated. This was perfect for below surface hydration (it felt like taking a biotin capsule, no crazy instant results but it helps later for sure!) and for the daytime routine when I can’t look like my nightly greaseball.
Will definitely repurchase when I get the chance!
Winner: Obviously, the Hylamide Low Molecular HA. Overall a more efficient HA serum that’s still affordable.
Where you can buy the products:
So, have you tried any of these products? Are you now interested if you haven’t yet? Sushi or Pizza? Let me know in the comments below!
Disclaimer: not a sponsored post. I’d honestly be flattered if you thought someone would sponsor me lol. Links are not affiliate links either. I have none of those.
Edit: forgot to edit this in but if anyone is interested in seeing somewhat regular skincare/food photos, follow me on IG @thegardensofasphodel! 💖